Fetal erythropoiesis in juvenile chronic myelocytic leukemia
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چکیده
منابع مشابه
Fetal erythropoiesis in juvenile chronic myelocytic leukemia.
Red cell enzymes, 2,3-diphosphoglycerate (2,3-DPG) and adenosine triphosphate (ATP), were evaluated in a 23-mo-old boy with juvenile chronic myelocytic leukemia (JCML) at the onset of his illness and 6 mo later during the accelerated phase. The activities of the age-dependent red cell enzymes, hexokinase, aldolase, pyruvate kinase, and glucose-6-phosphate dehydrogenase, were elevated, as were t...
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Two patients with chronic myelocytic leukemia who developed an erythroblastic rather than a myeloblastic phase were studied with respect to whether or not the megaloblastic erythropoiesis was subject to normal control mechanisms. After transfusion, no significant reduction was observed in the percentage of nucleated erythroid precursors or of proerythroblasts in marrow or in blood reticulocytes...
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Chronic myelocytic leukemia (CML)' is a clonal pluripotent stem cell disease, clinically divided into a chronic phase of a median duration of ^-4 yr, followed by an acute phase (blast crisis) lasting for few months (1) . Cytogenetic hallmark of most (95%) CML cases is the presence of the Philadelphia (Ph) chromosome, resulting from a reciprocal translocation between chromosomes 9 and 22 (2, 3) ...
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T HE OCCURRENCE of multiple cases of chronic myelocytic leukemia in a family is rare and, to our knowledge, has not been reported in identical twins. An analysis of such data may provide evidence for the existence of genetic factors in human leukemia. This is a report of the development of chronic myelocytic leukemia in identical twins and in one of their brothers. (Figure 1 ). In addition, epi...
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Juvenile chronic myelocytic leukemia (JCML) is a rare hematopoietic neoplasia of early childhood with distinct hematologic and biochemical features. We studied the biologic properties and the globin synthetic profiles of JCML erythroid cells both in vivo and in vitro from a total of 24 patients. In these cases we observed the exuberant colony-forming unit-macrophage (CFU-M) colony growth, as re...
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ژورنال
عنوان ژورنال: Blood
سال: 1983
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v62.3.602.bloodjournal623602